![]() ![]() sinensis have become increasingly used in medicinal products (Li et al. Thus, artificially cultured mycelia of H. sinensis are mannitol, cordycepin, purine nucleotides, pyrimidine nucleotides, unsaturated fatty acid, cordyceps polysaccharide and sphingolipid, which are consistent with the active ingredient in wild O. The main biological and pharmacological active ingredients in H. sinensis is expected to be an alternative of O. sinensis mycelia have been reported to have similar clinical efficacy and less associated toxicity compared with wild O. sinensis in molecular and genetic levels also would provide new insight into this organism and aid in its development and retention (Zhang et al. sinensis to discover valuable secondary metabolic functional genes, elucidate related metabolic pathways and to pave foundation for development of new approaches for pharmacological utilization. Because of its important applications in the Chinese traditional medicine, it is increasingly urgent to carry out the genetic studies of O. sinensis is almost exhausted in many areas (Huang et al. ![]() In recent years, due to high demand and the excessive excavation, the supply of O. sinensis was called as ‘golden Chinese traditional medicine’ (Chen et al. sinensis can only be obtained by field collection, so wild O. sinensis has activities to modulate immune responses, inhibit tumor cell proliferation, enhance hepatic function, regulate insulin sensitivity, decrease plasma cholesterol levels and modulate steroidogenesis (Cheung et al. sinensis,both of them be used to treat weakness after sickness, lung and kidney-associated diseases and sexual dysfunction (Buenz et al. There are high function similarities between wild O. sinensis is the only correct anamorph of O. sinensis has a long history in traditional Chinese medicine and Tibetan medicine (Sharma 2004 Winkler 2008). Ophiocordyceps sinensis, a fungus that parasitizes Lepidoptera larvae, has been used as a traditional medicine or healthy food in China for thousands of years (Zhang et al. The work presented here would improve the understanding of the genetic basis of this organism, and contribute to further research, production and application of H. sinensis were predicted and key enzymes were confirmed. The pathways of several active components in H. The genes and proteins were predicted and annotated based on the genome sequence. ![]() The enzymes involved in the infection mechanism were also predicted, cloned and expressed to verify the mechanism. sinensis were studied and elaborated in this article. Furthermore, infection process and mechanism of H. A detailed secondary metabolism analysis and structure verification of the main ingredients were performed, and the biosynthesis pathways of seven ingredients (mannitol, cordycepin, purine nucleotides, pyrimidine nucleotides, unsaturated fatty acid, cordyceps polysaccharide and sphingolipid) were predicted and drawn. 10,200 protein-encoding genes were predicted based on the genome sequence. sinensis (102.72 Mb) was obtained for the first time, with > 99% coverage. To gain deeper insight into the biological and pharmacological mechanisms, we sequenced the genome of H. sinensis is becoming more and more important and urgent. sinensis mycelium has similar clinical efficacy and less associated toxicity compared to the wild O. It is reported that the laboratory-grown H. Hirsutella sinensis was reported as the only correct anamorph of O. Ophiocordyceps sinensis has been used as a traditional medicine or healthy food in China for thousands of years. ![]()
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